GVF-Statement zu aktuellen Ergebnissen der Women´s Health Study zu Vitamin E (engl.)
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| GVF-Statement zu aktuellen Ergebnissen der Women´s Health Study zu Vitamin E (engl.) |
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Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer. The Women’s Health Study:
A Randomized Controlled Trial (Juli 2005)
Lee, I.M. et al.,
JAMA 294, 2005: 6th July 2005
Objective
Evaluate the benefits and risks of vitamin E supplementation (600 IU every other day) in the primary prevention of cardiovascular disease and cancer among healthy women.
Design
• Randomized, placebo-controlled
• Almost 40.000 healthy women (45 years of age and older) randomly assigned to receive vitamin E or placebo and aspirin or placebo, using a 2x2 factorial design
• Intervention dose: 600 IU vitamin E (RRR-alpha tocopherol) on alternate days
• Mean duration: 10.1 years of follow-up
Primary endpoints
• First major cardiovascular events (nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death
• Total invasive cancer
Results
• Significant 24% reduction (relative risk, 076; 95% confidence interval, 0.59-0.98; P=.03) for cardiovascular death
• Non-significant 7% risk reduction (relative risk, 0.93; 95% confidence interval, 0.82-1.05; P=.26) related to cardiovascular events in the vitamin E group
• No significant effects on incidences of myocardial infarction (relative risk, 1.01; 95%, confidence interval, 0.82-1.23; P=.96) or stroke (ischemic or haemorrhagic) (relative risk, 0.98; 95%, confidence interval, 0.82-1.17; P=.82)
• No significant effect on incidence of total cancer (relative risk, 1.01; 95%, confidence interval, 0.94-1.08; P=.87) or breast (relative risk, 1.00; 95%, confidence interval, 0.90-1.12; P=.95) or lung (relative risk, 1.09; 95%, confidence interval, 0.83-1.44; P=.52) or colon cancers (relative risk, 1.00; 95%, confidence interval, 0.77-1.31; P=.99)
• No significant effect on total mortality (relative risk, 1.04; 95%, confidence interval, 0.93-1.16; P=.53)
Author’s Conclusion
• 600 IU of vitamin E taken every second day provided no major benefit for major cardiovascular events or cancer, did not effect total mortality, but decreased cardiovascular mortality in healthy women.
• The data do not support recommending vitamin E supplementation for cardiovascular disease or cancer prevention among healthy women.